Department of Biochemistry and Biophysics
University of California, San Francisco
600 16th Street, S412, San Francisco, CA 94158
Telephone: 619-252-5078
Email: smriti@walterlab.ucsf.edu
Education
| Ph.D. | University of California, Los Angeles Molecular Biology | June 2017 |
| M.S. | University of California, Los Angeles Biomedical Engineering | June 2012 |
| B.Eng. | Maharshi Dayanand University, India Biotechnology | May 2009 |
Research
| University of California, San Francisco – Post Doctoral Fellow Advisors – Prof. Peter Walter and Prof. David Agard Co-translational mRNA Surveillance by the Unfolded Protein Response | Aug 2017 – |
| University of California, Los Angeles – Graduate Student Researcher Advisor – Prof. David Eisenberg Ph.D. Research Project -Structural studies of pathogenic amyloids | 2012-2017 |
Fellowships
| K99/R00 Pathway to Independence NIGMS Role: PI Molecular Mechanism of Translational Regulation | 2022-2027 |
| Helen Hay Whitney Post-Doctoral Fellowship Role: PI Co-translational surveillance by the Unfolded Protein Response | 2019-2022 |
| UCLA Graduate Division Dissertation Year Fellowship | 2016-2017 |
| Whitcome Pre-doctoral Fellowship | 2015-2017 |
Main Publications
- Schoof M*, Faust B*, Saunders RA*, Sangwan S*, Rezelj V*, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M; QCRG Structural Biology Consortium, Walter P, Manglik A. “An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation.” Science (2020) doi 10.1126/science.abe3255.*equal contribution
- Sangwan S*, Sahay S*, Murray K, Morgan S, Guenther E, Jiang L, Williams C, Vinters H, Goedert M and Eisenberg D “Inhibition of synucleinopathic seeding by rational designed inhibitors” eLife (2020). doi: 10.7554/eLife.46775.
- Sangwan S, Sawaya M, Murray K, Hughes M, Eisenberg D “Atomic structures of corkscrew-forming segments of SOD1 suggest molecular differences between toxic and non-toxic amyloid oligomers.” Protein Science (2018). doi: 10.1002/pro.3391. Cover Article
- Sangwan S, Zhao A, Adams K, Jayson C, Sawaya M, Guenther E, Soriaga A, Pan A, Ngo J, Moore D, Do T, Goldschmidt L, Nelson R, Bowers M, Koehler C, Shaw D, Novitch B, Eisenberg D “Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis.” Pro Natl. Acad Sci (2017) doi: 10.1073/pnas.1705091114.
- Sangwan S, Eisenberg D ‘Perspective on SOD1 mediated toxicity in Amyotrophic Lateral Sclerosis’ Review Postepi Biochemii (2016)
- Do D*, LaPointe N*, Sangwan*, Teplow D, Feinstein S, Sawaya M, Eisenberg D, and Bowers M. “Factors That Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants.” The Journal of Physical Chemistry B (2014) doi:10.1021/jp502473s. *equal contribution
Other Publications:
- Lawrence R, Shoemaker S, Deal A, Sangwan S, Anand A, Wang L, Marqusee S, Walter P“A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response signaling” bioRxiv, doi: https://doi.org/10.1101/2022.12.22.521453. 2022
- Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido E, Kwok S, Krogan N, Swaney D, Floor S, Sil A, Walter P, Mukherjee S. “A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response” bioRxiv, doi: https://doi.org/10.1101/2022.06.10.495705. 2022
- Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O’Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR 3rd, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH Jr, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D; QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL; Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. (2020) doi: 10.1126/science.abe9403.
- Do T, Sangwan S, de Almeida N, Ilitchev A, Giammona M, Sawaya M, Buratto S, Eisenberg D, Bowers M. Distal amyloid β-protein fragments template amyloid assembly. Protein Sci. 2018 Jan 19. doi: 10.1002/pro.3375.
- Soriaga A, Sangwan S, Macdonald R, Sawaya M, Eisenberg D “Crystal structures of IAPP amyloidogenic segments reveal a novel packing motif of out-of-register beta sheets” The Journal of Physical Chemistry B (2016)doi: 10.1021/acs.jpcb.5b09981
- Rodriguez J, Ivanova M, Sawaya M, Cascio D, Reyes F, Shi D, Sangwan S, Guenther E, Johnson L, Zhang M, Jiang L, Arbing M, Nannenga B, Hattne J, Whitelegge J, Brewster A, Messerschmidt M, Boutet S, Sauter N, Gonen T, Eisenberg D “Structure of the toxic core of α-synuclein from invisible crystals” Nature (2015) doi:10.1038/nature15368
Patents
D. Eisenberg, S. Sangwan, L. Jiang “STRUCTURE-BASED PEPTIDE INHIBITORS OF ALPHA-SYNUCLEIN AGGREGATION” UC 2015-567-1
Awards
| Future Faculty Fellow, Cornell University | 2023 |
| Rising Star in Engineering in Health jointly by Johns Hopkins University, Columbia University and Cornell University | 2023 |
| MERIT Emerging Leader, Memorial Sloan Kettering Cancer Center | 2023 |
| Next Generation Leader, Duke University | 2023 |
| D.E. Shaw Graduate and Postdoc Women’s Fellowship | 2021 |
| Dependent Care Award, UCSF | 2020 |
| HHMI Hanna Gray Fellowship, Finalist | 2018 |
| Fowler Award for Excellence in Protein Science | 2016 |
| Outstanding achievement award by MB-IDP, UCLA | 2014 |
| B.E. with Honors | 2009 |
Professional Development
| Inclusive Research Mentor Training (TRAIN-UP), UCSF | 2023 |
| Evidence Based Teaching Course (STEP-UP), UCSF | 2022 |
| Single-particle CryoEM Workshop, NYSBC | 2020 |
Teaching Experience
| Guest Lecturer, PROPEL, UCSF | 2023 |
| Mentor (Chemistry) in Summer Bridge Program at CEED, UCLA | 2013 |
| Teaching Assistant – MIMG 185 (Immunology) | 2012 |
| Teaching Assistant – MIMG 101 (Introductory Microbiology) | 2011 |
| Teaching Assistant – CHEM 153A (Introduction to Structure, Enzymes and Function) | 2011 |
Service and Outreach
| Ad hoc reviewer eLife, Nature Communications, Communications Biology, Nature Microbiology, Scientific Reports, Science Advances, Amyloid, PNAS, PeerJ and Frontiers in Molecular biosciences | 2017- |
| Mentor Summer Research Training Program, UCSF | 2019 |
| Mentor Rotation Students at UCLA and UCSF | 2015-2022 |
| Workshop Facilitator Summer Bridge Program at CEED, UCLA | 2013 |
Presentations
| University of Arizona, Department of Chemistry and Biochemistry | 2023 |
| University of Chicago, Rising Stars Symposium, Biological Sciences Division | 2023 |
| Cornell University, Rising Stars in Engineering in Health Symposium | 2023 |
| Cornell University, Department of Molecular Biology and Genetics, Future Faculty Symposium | 2023 |
| Albert Einstein College of Medicine, Program for RNA Biology | 2023 |
| Sloan Kettering Institute, MERIT Emerging Leaders Symposium | 2023 |
| University of Southern California, Department of Pharmacology and Pharmaceutical Sciences | 2023 |
| UCLA, Structural Biology Group Meeting | 2023 |
| FASEB SRC, ER Conference -Structure, Function and Disease | 2023 |
| Duke University, School of Medicine, Next Generation Leaders Symposium | 2023 |
| University of Massachusetts, Amherst, Department of Biochemistry and Molecular Biology | 2023 |
| DE Shaw Symposium | 2021 |
| Gordon Research Conference and Seminar, Neurobiology of Brain Disorders | 2016 |
| Keystone Symposia, Common Mechanisms of Neurodegeneration | 2016 |
| NINDS Meeting, How Can Protein Structure Help Us Unravel the Mysteries of Neurodegenerative Diseases. | 2015 |
| FASEB SRC Conference, Molecular Mechanisms and Physiological Consequences of Protein Aggregation | 2015 |
| UCLA, Biological Chemistry Seminar Series | 2015 |
| Salk Institute, Symposium on Neurodegenerative diseases | 2015 |
| UCLA, Biological Chemistry Seminar Series | 2014 |
| CSHL conference, Neurodegenerative diseases | 2014 |
| FASEB SRC Conference, Molecular Mechanisms and Physiological Consequences of Protein Aggregation | 2013 |
References
| Prof. Peter Walter Professor Department of Biochemistry and Biophysics University of California, San Francisco pwalter@altoslabs.com 415-476-4636 | Prof. David Agard Professor Department of Biochemistry and Biophysics University of California, San Francisco agard@msg.ucsf.edu 415-476-2521 |
Prof. David Eisenberg Professor Department of Chemistry and Biochemistry University of California, Los Angeles david@mbi.ucla.edu 310-825-3754 | Prof. Aashish Manglik Associate Professor Department of Pharmaceutical Chemistry University of California, San Francisco Aashish.Manglik@ucsf.edu 415-502-3744 |
Smriti Sangwan, PhD 